منابع مشابه
Gene Therapy for Color Blindness
Achromatopsia is a rare congenital cause of vision loss due to isolated cone photoreceptor dysfunction. The most common underlying genetic mutations are autosomal recessive changes in CNGA3, CNGB3, GNAT2, PDE6H, PDE6C, or ATF6. Animal models of Cnga3, Cngb3, and Gnat2 have been rescued using AAV gene therapy; showing partial restoration of cone electrophysiology and integration of this new phot...
متن کاملGene Therapy for Red-Green Color Blindness
Red-green color blindness, “Daltonism,” is the most common single locus genetic disorder, affecting 6% of men worldwide. Gene therapy is a potential means of correcting the defective or missing locus through the injection/transplantation of a normal transgene. Through the evaluation of one case study, gene therapy has cured colorblindness in squirrel monkeys, and may provide promise for humans.
متن کاملColor-Vision and Color-Blindness
Special public attention was called to the subject in 1875 by an enquiry into the causes of a railway accident which had taken place in Sweden, from which it appears that colourblindness was the cause of the disaster. Our author having described colour-sensations, goes on to discuss the theories of colour-perception and colour-blindness, classifying the latter defect as total and partial. Total...
متن کاملCortical color blindness is not "blindsight for color".
Cortical color blindness, or cerebral achromatopsia, has been likened by some authors to "blindsight" for color or an instance of "covert" processing of color. Recently, it has been shown that, although such patients are unable to identify or discriminate hue differences, they nevertheless show a striking ability to process wavelength differences, which can result in preserved sensitivity to ch...
متن کاملGene therapy for blindness.
Sight-restoring therapy for the visually impaired and blind is a major unmet medical need. Ocular gene therapy is a rational choice for restoring vision or preventing the loss of vision because most blinding diseases originate in cellular components of the eye, a compartment that is optimally suited for the delivery of genes, and many of these diseases have a genetic origin or genetic component...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2000
ISSN: 1474-760X
DOI: 10.1186/gb-2000-1-5-reports0074